Promoting remyelination in multiple sclerosis
نویسندگان
چکیده
منابع مشابه
Promoting Remyelination in Multiple Sclerosis—Recent Advances
We review the current state of knowledge of remyelination in multiple sclerosis (MS), concentrating on advances in the understanding of the pathology and the regenerative response, and we summarise progress on the development of new therapies to enhance remyelination aimed at reducing progressive accumulation of disability in MS. We discuss key target pathways identified in experimental models,...
متن کاملPromoting remyelination in multiple sclerosis: current drugs and future prospects.
Myelin destruction due to inflammatory oligodendrocyte cell damage or death in conjunction with axonal degeneration are among the major histopathological hallmarks of multiple sclerosis (MS). The majority of available immunomodulatory medications for MS are approved for relapsing-remitting (RR) MS, for which they reduce relapse rate, MRI measures of inflammation, and the accumulation of disabil...
متن کاملRemyelination Therapy in Multiple Sclerosis
Multiple sclerosis (MS) is an immune-mediated disorder of the central nervous system that results in destruction of the myelin sheath that surrounds axons and eventual neurodegeneration. Current treatments approved for the treatment of relapsing forms of MS target the aberrant immune response and successfully reduce the severity of attacks and frequency of relapses. Therapies are still needed t...
متن کاملDemyelination versus remyelination in progressive multiple sclerosis.
The causes of incomplete remyelination in progressive multiple sclerosis are unknown, as are the pathological correlates of the different clinical characteristics of patients with primary and secondary progressive disease. We analysed brains and spinal cords from 51 patients with progressive multiple sclerosis by planimetry. Thirteen patients with primary progressive disease were compared with ...
متن کاملPromoting Remyelination and Preventing Demyelination New Research Goals in Finding a Therapy for Multiple Sclerosis
Recent Multiple Sclerosis (MS) research has made it apparent that demyelination has further consequences than its primary effects of inflammation and impaired conduction. It is now well understood that demyelination leads to significant progressive axonal and neuronal degeneration. This finding explains why patients receiving immunosuppressive therapies still show disease progression – they hav...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neurology
سال: 2019
ISSN: 0340-5354,1432-1459
DOI: 10.1007/s00415-019-09421-x